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Ferrous ion has the effect of mediating ROS production and enzyme activity during lipid peroxidation, which can produce a large number of ROS through the Fenton reaction ( The System X c /GSH/GPX4 axis is an important antioxidant system ferroptosis

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AOD-9604 lacks this broad receptor engagement, confining its research activity to lipolytic pathways, which makes it a more targeted and mechanistically distinct compound for metabolic research models